Its important to go to all of your appointments and talk to your provider about any questions or concerns you have. Depending on the severity of symptoms, other treatments may be necessary as well. Cleveland Clinic is a non-profit academic medical center. Does It Allow for Dietary Restrictions or Preferences? Medications can also work differently if they are taken on an empty stomach. If you develop a deep vein thrombosis or pulmonary embolism, your provider will prescribe an anticoagulant. About 1 of every 250 Black people in America has the prothrombin gene mutation. 0000000856 00000 n This mutation can increase your chance of developing abnormal blood clots, most commonly in your legs or lungs. Food choices are varied enough that you can have a balanced diet and not get bored of foods. 2018;43 (5) (Specialty&Oncology suppl):12-15. Mayo Clinic does not endorse companies or products. Factor V and other proteins work together to help your blood clot when necessary. 0000006722 00000 n How does prothrombin gene mutation affect my body? Symptoms of a blood clot depend on what part of your body is affected. Youll spend roughly the same amount on groceries if you keep the bulk of your protein purchases to eggs, lean meats and poultry, and fat-free dairy, as opposed to seafood. you have a medical emergency, call 911 immediately. This change causes it to resist other proteins that stop excessive clotting. If you are already taking an anticoagulant, make sure you keep regular appointments with your provider. There are many foods that can be beneficial to the health of patients with Factor V Leiden. on this website is designed to support, not to replace the relationship 0000236831 00000 n AskMayoExpert. Accessed June 4, 2018. Low-salt, low-fat: The plan is already geared toward low-fat and low-salt foods and may be adjusted further if needed. As they come, write them down. professional diagnosis, opinion, treatment, or services to you or any individual. "Anticoagulant Food-Drug Interactions". But if you do develop clots, be assured there are treatments that can help. Is this an emergency? In: Williams Hematology. Exercise regularly, such as walking, swimming or riding a bike 3 times a week. Bauer KA. Yes, you may be able to donate blood if youre not taking a blood thinner. Enjoy a variety of foods from the 4 food groups. This mutation can increase your chance of developing abnormal blood clots, most commonly in your legs or lungs. These precautions might include: Some precautions to help reduce your risk of blood clots include: If your factor V Leiden requires you to take anticoagulant medication, here are some steps that might help you prevent injury and avoid excessive bleeding: Your doctor may refer you to a specialist in genetic disorders (geneticist) or a specialist in blood disorders (hematologist) for testing to determine whether the cause of your blood clots is genetic and, specifically, whether you have factor V Leiden. In the spring of 2010, I was working and felt that it was a little difficult to bend my right knee / walk - I felt very little swelling / heat so I thought little of it, especially in light of a prior history of having knee problems in that same leg. Information on diseasemaps.org is reported by users and is not medical advice. Recurrent fetal loss during the second or third trimester suggests an inherited thrombophilia or antiphospholipid antibody. Does my factor V Leiden need to be treated? Youre might be wondering, Will this happen to me? Most people with this disorder never develop a blood clot. 04 March 2023. This will help to avoid miscarriage or pregnancy complications for the following reasons: . https://www.news-medical.net/health/Anticoagulant-Food-Drug-Interactions.aspx. Factor V Leiden causes hypercoagulability, which makes it harder for your blood clots to break up. Talk to your doctor about your fitness goals before starting this program. 8( x@YB.X0v@+::0Xv|@Q-s4>p03(/` `F0.oCD8}.n)2`b#jPv!A CPt k*6@)V+`b@@\crT0. Low Vitamin K consumption if on Coumadin/Warfarin. If you have never had a blood clot, you do not need treatment with blood thinners. Middeldorp S, Coppens M. Hereditary Thrombophilia. Eat well. Kaushansky K, et al., eds. 9500 Euclid Avenue, Cleveland, Ohio 44195 |, Important Updates + Notice of Vendor Data Event, (https://pubmed.ncbi.nlm.nih.gov/31577252/), (https://www.stoptheclot.org/factor-v-leiden/). 0000003776 00000 n AHA: "Shaking the Salt Habit to Lower High Blood Pressure", Harvard T. H. Chan School of Public Health: "Vitamin K", AHA: "Understanding Your Risk for Excessive Blood Clotting", Using hormone therapy, including birth control pills, Immobility, either from lack of exercise, disability or sitting for long periods of time. A food-drug interaction is when a particular food or drink affects the way in which a certain medication works. If you believe The condition it self does not require a special diet. Most people with factor V Leiden never develop abnormal clots. Barbara Woodward Lips Patient Education Center. Venous thromboembolism. More info. Prevention and Treatment of Excessive Blood Clotting (Hypercoagulation). 0000003297 00000 n The exercise portion of the program might have to be changed if you are trying to follow the exercise guidelines of the American Heart Association. In situations where there is a greater chance of clotting (such as surgery, a leg cast, a serious illness or pregnancy) you may be treated with blood thinners until the risk has passed. Rochester, Minn.: Mayo Foundation for Medical Education and Research; 2017. If youre having a deep vein thrombosis or pulmonary embolism, your provider will typically treat you with anticoagulants (blood thinners) and occasionally with thrombolytic (clot-busting) medicines. Factor V Leiden thrombophilia. 0000001914 00000 n In your body, you have 50% Factor V Leiden and 50% normal Factor V. This happens in about 5 out of 100 people of Caucasian decent. Green tea in high amounts could reduce PT-INR values. Be active in ways you enjoy. Clotting Disorders. They are prescribed to avoid the development of harmful blood clots. The mutation does not cause any symptoms in and of itself. The factor V Leiden mutation does not itself cause any symptoms. If you have this disorder, you may experience: Factor V Leiden doesnt raise your risk of heart attacks, strokes or blood clots in the arteries of your legs. In rare cases, you may need a catheter procedure or surgery to remove the bulk of the clots. Accessed June 4, 2018. Factor V Leiden (FAK-tur five LIDE-n) is a mutation of one of the clotting factors in the blood. WebMD does not provide medical advice, diagnosis or treatment. If you are homozygous, you will pass the mutation on to your children. Did I get the mutation from both parents or just one? Make a donation. In fact, the vast majority (9 out of 10) never develop abnormal blood clots. Leg wraps that inflate and deflate to keep blood moving in your legs. Do I need to limit my activity in any way? As a result, factor V works in overdrive, making your blood more likely to clot when it shouldnt. advice, care, or treatment. If youre taking anticoagulants (blood thinners), be aware that you may bleed or bruise more easily, which is why it is very important to have regular follow-up medical appointments with your provider. 2005 - 2023 WebMD LLC. There needs to be a balance of these proteins to make sure there is just enough clotting power: Factor V is one of the proteins needed to make blood form clots. If you have factor V Leiden, there are other ways you can help reduce your risk of developing a blood clot beyond your diet. You may never get a dangerous clot, but its helpful to know the warning signs in case you do. >_IJ9D/\KwrokzHI7lw7B+Vefcr2L`/R6:s#oI`HlG&W|Az_hSafLG*!~?k{Xi|2`7Q\GcLb9'I |./(-k$Bw&uooR`";j$6GKE:t.0V* II'LX2Q074H4bXh. 3&&}o#Rf,M%>i_+23#_~Ub7{1e9O6I@iQ>,L8?@e"XFExot!^>P(@|` 9 ;90{7,N9|Xf@68-VQBaqL8E-u^5iT Id9l'U"ec BW">)W#idirh#Z>w(!($|1Pa_-780 E71>CCJ8VF}mAGLS!qqEb3 1AEd 'DG/syWtbhF#'. THE DOCTORS COULD NOT FIGURE OUT WHERE MY BLOOD CLOTS WERE COMING FROM SINCE I DID NOT HAVE ANY DVT'S. But if you do, prompt treatment can manage your condition. For instance, they may work faster or slower, more or less effectively, or cause digestive problems. It may ease your mind to know that most people with this disorder never have a blood clot. ABSTRACT: Factor V Leiden thrombophilia is a genetic disorder that may increase a patient's risk of developing a venous thromboembolism (VTE). This content does not have an Arabic version. Do I need to take medication to prevent additional blood clots? Added sugars in excess of 24 grams per day for people assigned female at birth and 32 grams per day for people assigned male at birth, per the American Heart Association. Lois is a freelance copywriter based in the UK. https://www.uptodate.com/contents/search. If you inherited 1 Factor V Leiden gene from one parent, you have the heterozygous type of Factor V Leiden. Connect with others like you for support and answers to your questions in the Blood Cancers & Disorders support group on Mayo Clinic Connect, a patient community. If you have the heterozygous type, there is a 50% chance that your child will inherit a Factor V Leiden gene from you. 9500 Euclid Avenue, Cleveland, Ohio 44195 |, Important Updates + Notice of Vendor Data Event, (https://medlineplus.gov/genetics/condition/prothrombin-thrombophilia/#resources). If you have Factor V Leiden, you have a greater chance of developing blood clots. There is also a 50% chance that your child will inherit your normal Factor V gene. If your provider feels its warranted, theyll order blood tests, including: Simply having a family history of blood clots may not be reason enough to run these tests. Laboratory testing (blood tests) diagnose this disorder. Coming to a Cleveland Clinic location?Hillcrest Cancer Center check-in changesCole Eye entrance closingVisitation, mask requirements and COVID-19 information, Notice of Intelligent Business Solutions data eventLearn more. Factor V Leiden G1691A and Prothrombin Gene G20210A Mutations on Pregnancy Outcome. Fewer than 1 in 100 people of Asian descent. Factor V that becomes impaired can cause numerous issues with the health of the human blood. Avoid smoking, vaping and tobacco use. Everyone is born with two copies of the factor V pronounced factor five gene. Talk with your doctor about the risks and benefits of taking these medications. Make a donation. Your provider may think you have a clotting problem if you: There is no specific treatment for the mutation itself. Alcohol interacts with a large number of medications. What types of side effects can I expect from the medication? Heterozygous Factor V Leiden If you inherited one Factor V Leiden gene from one parent, you have the heterozygous type of Factor V Leiden. If you know you have the factor V gene mutation, you can work to make your body an inhospitable place for clots, starting with something under your control: your diet. If youcannot reach your doctor, go to the nearest hospital emergency room. Will Eating More Protein Help Your Body Gain Muscle Faster? (https://www.heart.org/en/health-topics/venous-thromboembolism/prevention-and-treatment-of-excessive-blood-clotting-hypercoagulation), (https://www.redcrossblood.org/donate-blood/how-to-donate/eligibility-requirements/eligibility-criteria-alphabetical.html), Visitation, mask requirements and COVID-19 information, Heart, Vascular & Thoracic Institute (Miller Family). Most notably, you will need to be aware of your vitamin K consumption. It is important to note that alcohol also has some anticoagulant action and can protect adults from blood clots, although it is not recommended as a preventative measure for this purpose. Foods high in saturated fat, including animal and dairy fat, coconut oil, palm oil and processed meat. Cranberry juice and other cranberry products can alter the effects of anticoagulants. The NATIONAL BLOOD CLOT ALLIANCE works to advance #bloodclot awareness, prevention, diagnosis, & successful treatments to #stoptheclot. But because there are many risk factors associated with the development of those pregnancy complications, theres still debate and uncertainty as to how much the factor V Leiden mutation is a cause or just another contributing factor to those pregnancy complications. INR values of between 2.0 and 3.0 are considered effective therapeutic values while on anticoagulant therapy. What will a positive or negative result tell me? There is no specific treatment for the mutation itself. Youll have the prothrombin gene mutation for life, since its part of your genetic makeup. Inherited thrombophilias in pregnancy. .wpcdt-timer-24806 .wpcdt-clock .wpcdt-digits, News-Medical.Net provides this medical information service in accordance Talk to your provider to see if you should be taking a blood thinner. 0000229756 00000 n https://rarediseases.info.nih.gov/diseases/6403/factor-v-leiden-thrombophilia. Both men and women can have factor V Leiden. In general, its more common among people who are white in the U.S. and Europe. Fruits and vegetables: Get at least five servings of fruits and veggies throughout the day, and incorporate all different kinds. Lean protein: Prioritize lean proteins such as chicken, turkey and lean beef. Some issues that can be discussed with your doctor include: Other than the increased risk of developing DVT or PE, factor V Leiden may increase the risk of miscarriage or other pregnancy complications, such as preeclampsia and eclampsia, placental abruption (when the placenta separates too early from the wall of your uterus), and having a fetus that grows slower than is usual. There currently arent any genetic treatments that can stop someone from inheriting a mutated F5 gene. Factor V Leiden is an inherited blood clotting disorder that raises your risk of deep vein thrombosis or a pulmonary embolism. 9th ed. Doctors generally prescribe blood-thinning medications to treat people who develop abnormal blood clots. For factor V Leiden, some basic questions to ask your doctor include: If your doctor recommends genetic testing, some questions you might want to ask the genetic specialist include: Connect with others like you for support and answers to your questions in the Blood Cancers & Disorders support group on Mayo Clinic Connect, a patient community. As a result, too much blood clotting can happen. This change causes factor V to resist the actions of other proteins (protein C and protein S), which normally inactivate factor V when needed to keep your blood from clotting abnormally. That risk is several times higher in homozygous carriers. . 4. Miscarriages associated with factor V Leiden are more likely to occur later in pregnancy (after the first trimester). The prevalence of factor V Leiden varies by ethnicity. Anticoagulants, commonly called blood thinners, are a group of medications that impede the blood clotting process. When anticoagulants are prescribed, a prothrombin time (PT) test is used to evaluate its effectiveness. A variety of herbs and vitamins may interact with anticoagulants. For those who are watching their cholesterol, there have been some studies that show low GI diets are helpful at lowering cholesterol levels. Self-care therapies to support your reproductive health; News-Medical. News-Medical. Diseasemaps 2023, FACTORV LEIDEN AND LIVEDOID VASCULOPATHY SURVIVOR. Accessed June 4, 2018. Cost: Just your groceries. Yes, you can pass on the gene for this disorder to your children. HW}Wc)h"Y$ x N,@I)T7;&?/s"C0]=wSb;{PlYdA&Trb"agbH0Hok8bio@k'q Factor V Leiden and activated protein C resistance. If you have factor V Leiden, you may have many questions. In most people, a protein called activated protein C regulates the activity of . Children who are healthy and do not have factor V Leiden will get a blood clot in one out of 50,000-100,000 . She maintains a focus on anxiety disorders and depression and aims to explore other areas of mental health including dissociative disorders such as maladaptive daydreaming. This content does not have an English version. It is not a disease. (accessed March 04, 2023). A mutation in your F5 gene causes this disorder, which follows an autosomal dominant inheritance pattern. But if you have a blood clotting disorder, your blood forms clots more easily than normal. Since factor V Leiden is a risk for developing blood clots in the leg or lungs, the first indication that you have the disorder may be the development of an abnormal blood clot. Blood clots in the deep veins in your legs (called deep vein thrombosis or DVT) or in your lungs (called pulmonary embolus or PE) can be dangerous. If you have kidney disease, there may be too much protein in this diet for you. Accessed June 4, 2018. If you inherited 2 Factor V Leiden genes, you have the homozygous type of Factor V Leiden. 3. Factor V is a protein that is needed for blood to clot properly. If you notice any of these problems, call your doctor right away. www.phac-aspc.gc.ca/pau-uap/paguide/. The Top 5 Worst Foods for Your Heart, According to a Dietitian. 0000022790 00000 n It does not increase the risk of myocardial infarction (heart attacks) or arterial strokes. Fruits and vegetables: Get at least five servings of fruits and veggies throughout the day, and incorporate all different kinds. This disorder may raise your risk of a miscarriage or other complications. Carbohydrates with lower glycemic index (GI) values raise blood sugar levels less than foods with a higher GI, but their use in weight loss has not been as well studied. 0000003221 00000 n Since then I was also diagnosed w My name is MARTIN R. LEMIEUX, and for over 20 years now Ive survived five DVTS BLOOD CLOTS in my left leg, one clot in my right leg, and another clot in my left pelvic area. Healthy fats: Eat healthy fats each day such as olive oil, nuts, seeds and avocado. But your provider can help you keep your blood from clotting too much. Exercise regularly for good circulation in the veins of your legs. But you will have to be careful about how much fat and salt you are eating, as well, if you were told to limit them in your diet. Our mission of spreading lifesaving #bloodclot awareness is possible thanks to the generous support of our partners. (https://www.stoptheclot.org/learn_more/prothrombin-g20210a-factor-ii-mutation-links/), (https://www.merckmanuals.com/home/blood-disorders/excessive-clotting/excessive-clotting?query=prothrombin%20gene%20mutation). This type of medicine usually isn't needed for people who have the factor V Leiden mutation but who have not experienced abnormal blood clots. Policy. Want to talk about Multiple Myeloma: Anyone else? Policy. Factor V Leiden. A single copy of these materials may be reprinted for noncommercial personal use only. The Meat Effect: Protein, Carbs, and Your Diet. I was diagnosed in 2001 after a series of TIA's and a smart neurologist who suspected there was something more to be investigated since I had a history of DVT's and my mother's family has had numerous blood clots. 0000003553 00000 n Wear compression stockings if your provider prescribes them for you. Symptoms of a deep vein thrombosis or pulmonary embolism typically start getting better soon after specific treatment is started. Hereditary thrombophilia. During long car rides, stop every few hours and take a short walk. The risks of food-drug interactions include preventing the proper working of a medication, causing unwanted side effects, and changing the way the body uses ingested food or beverages while on the medication. 0000002579 00000 n Women have a greater chance of developing a blood clot during pregnancy. As a result, your blood may clot more easily than it should, leading to serious complications. https://rarediseases.info.nih.gov/diseases/6403/factor-v-leiden-thrombophilia. Lockwood CJ, et al. You may not need to do anything other than lead a healthy lifestyle to minimize the risk of a deep vein thrombosis or pulmonary embolism. When you are ready, talk with your health care provider for advice and help to stop smoking. It is generally advised that patients taking anticoagulants keep to a balanced and consistent diet balanced throughout their treatment course to avoid fluctuations in treatment efficacy. Do you know someone who has suffered a deep vein thrombosis, pulmonary embolism, or other type of venous blood clot? .wpcdt-timer-24806 .wpcdt-clock .wpcdt-lbl{color: #ffffff;}.wpcdt-timer-24806 .wpcdt-clock-circle span, Your child will have either the heterozygous or homozygous type, depending on whether the gene passed down from his or her other parent is normal (Factor V) or abnormal (Factor V Leiden).